Angela James, an Executive Editor, provides a little insight into editors and their evaluations of manuscripts.
Shortcut or short stick?
If you ever get the chance to submit your novel directly to an editor, think twice. You get only one shot as Kristin Nelson explains:
First being that editors who take submissions directly log those submissions. So if one editor has passed, it will be on record so that pretty much nixes it for any other editor at that imprint.
… even if that newer editor loves it, she’s going to have to get second reads and support to take it to ed. Board. Well, if that senior editor nixed it and then it pops up again, well, it’s going to get shot down again. And on top of that, the newer editor is not going to have very warm feelings toward you for putting her in an awkward position.